The span of six years between Till Death Do Us Part and Rise Up marks Cypress Hill's longest gap between studio albums in their career. The group commenced work on the record in 2005, but had not entered studio work until 2008.[5] The writing and recording process spanned four years and a number of recording studios and was finished in 2009.

Rise Up was delayed several times before its release. Originally scheduled to be released in 2006, it was later postponed to March 23, 2010 (exactly six years since the release of their last album), then again to April 6. The album's release date was finally set for April 20, 2010.

In terms of the album's musical direction, in March 2010 Cypress Hill emcee B-Real told noted UK urban writer Pete Lewis - Deputy Editor of the award-winning Blues & Soul - "Musically we wanted a bigger sound, a more AGGRESSIVE sound, and something obviously with a lotta DYNAMICS. You know, our sound has always been raw and gritty, ominous and moody... And, while this time we still wanted it to be raw and dark, we also wanted it to be more UPTEMPO. Because, in terms of the live setting, whenever we do songs that are more uptempo and aggressive people do love them and it makes for a great SHOW. So, while making this album, we definitely had the intention of making songs that would translate well to the live aspect of what Cypress Hill is about. So that, when we play these songs out, we're gonna get a magnificent reaction from the crowd!"



                           Tracklist
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1. It Ain’t Nothin’ f Young De (prod. B-Real)
2. Light It Up (prod. Pete Rock)
3. Rise Up f. Tom Morello (prod. Tom Morello & B-Real)
4. Get It Anyway (prod. Jim Jonsin)
5. Pass The Dutch f. Evidence & Alchemist (prod. DJ Muggs & DJ Khalil)
6. Bang Bang (prod. B-Real)
7. K.U.S.H (prod. Sick Jacken & B-Real)
8. Get ‘Em Up (prod. B-Real)
9. Carry Me Away f. Mike Shinoda (prod. Mike Shinoda)
10. Trouble Seeker f. Daron Malakian (prod. Daron Malakian)
11. Day Destroys the Night f. Everlast (prod. DJ Muggs & DJ Khalil)
12. I Unlimited (prod. B-Real)
13. Armed & Dangerous (prod. Jake One & B-Real)
14. Shut ‘Em Down f. Tom Morello (prod. Tom Morello & B-Real)
15. Armada Latina f. Marc Anthony & Pitbull (prod. Jim Jonsin)